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2000, 03, 14-15
血清脂蛋白Lp(a)的测定与型糖尿病大血管病变的关系
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目的 :研究血清脂蛋白 (a)的浓度和糖尿病的大血管并发症的关系。方法 :用酶联免疫吸附法定量测定 5 0例 型糖尿病患者和 5 0例正常人的血清脂蛋白 (a)水平 ,同时对糖尿病合并有大血管病变患者与无血管病变的患者的脂蛋白 (a)进行对比分析。结果 :糖尿病患者脂蛋白 (a)水平明显高于正常对照组 ,糖尿病患者有大血管病变组脂蛋白 (a)水平较无大血管病变组升高尤其显著。结论 :脂蛋白 (a)与糖尿病 型大血管病变的发生有密切的关系

Abstract:

Objective: To investigate the relationship between the serum Lp(a)and macrovascular complications of type Ⅱ diabetic patients .High serum Lp(a) concentration may be associated with a high risk of macrovascular complications in type Ⅱ diabetic. Methods: The subjects are 50 type Ⅱ diabetes patients(25 with macrovascular complications and 25 without macrovascular complications)and 50 normal subjects, we use the ELISE to measure the serum Lp(a) in both type Ⅱ diabetes and normal People. Results: Diabetic serum Lp(a) concentration is nigher than mormal pelple, and serum Lp(a) concentration in diabetes with macrovascular complications is higher than those without mactovascular complications. Conclusion: Serum Lp (a) is strongly associated with type Ⅱ diabetic macrovascular complications.

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参考文献

1  Chang CJ,Kao JT,WU TJ.Serum lipids and lipopro-tein(a) concentrations in Chinese NIDDM patients.Re-lation to metabolic control.Diabetes Care,1995 ,18(8) :1191- 4

2  Chico A,Pou JM,de L eiva A.L ipoprotein(a) concentra-tions and non- insulin- dependent diabetes mellitus:rela-tionship to glycaemic controland diabetic com plications.Diabetes Res Clin Pract,1996 ,33(2 ) :10 5 - 10

3  Heller FR,Jamart J,Honore P.Serum lipoprotein(a) inpatients with diabetes m ellitus.Diabetes Care,1993,16(5 ) :819- 2 3

4  Jenkins AJ,Best JD.The role of lipoprotein(a) in thevascular complications of diabetes m ellitus.J InternMed,1995 ,2 37(4 ) 35 9- 6 5

5 沈稚舟 ,吴松华 ,邵福源 ,等 .糠尿病慢性并发症 .上海 :上海医科大学出版社 ,1993.31- 33

6 韩萍 ,郭津津 ,郭阳 ,等 .血浆糖化低密度脂蛋白 .脂蛋白 (a)与 型糖尿病大血管病变的关系 .中国糖尿病杂志 ,2 0 0 0 ,8:30

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中图分类号:R587.102

引用信息:

[1]许红俊,仇克难.血清脂蛋白Lp(a)的测定与型糖尿病大血管病变的关系[J].武汉市职工医学院学报,2000(03):14-15.

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