江汉大学学报（自然科学版）

目的探讨中性粒-淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)对新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者预后评估的价值。方法采用回顾性研究的方法,选择收治的399例COVID-19为研究对象,根据临床预后,分为生存组(375例)和死亡组(24例),收集患者入科第1天中性粒细胞计数、淋巴细胞计数以计算NLR,比较中性粒细胞、淋巴细胞、NLR在不同组间的差异;采用受试者工作特征(ROC)曲线评价NLR预测预后的最佳阈值。结果死亡组的中性粒细胞、NLR明显高于生存组,死亡组的淋巴细胞计数明显低于生存组。通过ROC曲线分析发现中性粒细胞、淋巴细胞、NLR的ROC曲线下面积分别为0. 759、0. 838、0. 856,最佳工作点分别为4. 955×109/L、0. 775×109/L、6. 919。结论NLR可以作为一个简便有效的辅助指标用于COVID-19患者的预后评估。

Objective To explore the assessment value of neutrophil-to-lymphocyte ratio(NLR) for prognosis in coronavirus disease 2019(COVID-19). Methods Using the retrospective study,399 cases of COVID-19 admitted to Wuhan Fourth Hospital were selected as the research subjects. According to the clinical prognosis,they were divided into the survival group(n = 375) and the death group(n = 24). The neutrophil count and lymphocyte count of patients on the first day of admission were collected to calculate the NLR,and the differences between neutrophils,lymphocytes and NLR in different groups were compared. The receiver-operating characteristic(ROC) curve was used to evaluate the optimal threshold of NLR for predicting prognosis. Results The neutrophils and NLR of the death group were significantly higher than that of the survival group, and the lymphocytes of the death group were significantly lower than that of the survival group.According to ROC curve analysis, the areas under the ROC curve of neutrophils,lymphocytes and NLR were 0. 759, 0. 838 and 0. 856, respectively, and the optimal thresholds were 4. 955 × 109/L,0. 775 × 109/L,and 6. 919,respectively. Conclusion NLR can be used as a simple and effective auxiliary indicator for prognostic evaluation of COVID-19 patients.