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目的观察左旋四氢帕马丁(levo-tetrahydropalmatine,l-THP)对条件线索诱导的大鼠甲基苯丙胺复吸行为的影响。方法雄性SD大鼠利用固定比率程序(fixed ratio 1,FR1)建立起大鼠甲基苯丙胺自身给药模型,模型建立成功戒断14 d后,随机分为4组,腹腔注射0、1.25、2.50和5.00 mg/kg l-THP,观察不同剂量的l-THP对条件线索诱导的大鼠甲基苯丙胺复吸行为的影响。结果在条件线索诱导的复吸行为测试中,与0 mg/kg l-THP组相比,1.25、2.50和5.00 mg/kg l-THP组能显著降低大鼠固定比率下的有效鼻触次数(P<0.01);1.25、2.50和5.00 mg/kg l-THP组无效鼻触次数与0 mg/kg l-THP组相比无明显差异(P>0.05)。结论 1.25、2.50和5.00 mg/kg l-THP能抑制条件线索诱导的大鼠甲基苯丙胺复吸行为。
Abstract：Objective To investigate effects of levo-tetrahydropalmatine(l-THP)on the reinstatementof methamphetamine induced by conditioned cues in rats. Methods Rats were trained to self-administermethamphetamine under fixed ratio 1(FR1)scheduler until stable responding was established. Follow-ing withdrawal(14d),rats randomly divided into four groups. Each group respectively received one dos-es of l-THP treatment(0,1. 25,2. 50,5. 00 mg/kg,i. p.)and cues-induced methamphetamine seek-ing behavior was recorded. Results As compared with 0 mg/kg l-THP pretreatment group, l-THP(1. 25,2. 50,5. 00 mg/kg,i. p.)pretreatment group significantly decreased the number of active nosepoke( P < 0. 01). In contrast,inactive nose poke had no significantly difference(all P > 0. 05).Conclusion l-THP(1. 25,2. 50,5. 00 mg/kg,i. p.)can inhibit the reinstatement of methamphet-amine induced by cues in rats.
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基本信息:
DOI：10.16389/j.cnki.cn42-1737/n.2016.05.007
中图分类号:R749.64
引用信息:
[1]龚晓康,乐凯,马宝苗等.左旋四氢帕马丁对条件线索诱导的大鼠甲基苯丙胺复吸行为的影响[J].江汉大学学报(自然科学版),2016,44(05):422-426.DOI:10.16389/j.cnki.cn42-1737/n.2016.05.007.
基金信息:
国家自然科学基金青年项目(81302762); 江汉大学研究生科研创新基金项目