| 343 | 13 | 11 |
| 下载次数 | 被引频次 | 阅读次数 |
胰岛素样生长因子-1(IGF-1)是一种与生长激素产生生理作用过程息息相关的活性蛋白多肽物质,可以促进糖类、脂类、蛋白质和无机盐的代谢。然而,IGF-1长期使用给患者带来的不良反应大大限制了它的临床应用,为了扩大IGF-1在医学领域的应用,科研工作者正积极开发IGF-1相关的衍生物。综述了采用基因工程和分子生物学技术合成的截短型IGF-1、加长型IGF-1、IGF-1-Fc融合蛋白和聚乙二醇化的IGF-1衍生物,阐释了IGF-1衍生物优良的生物学功能,可为其他蛋白类药物的研发提供指导。
Abstract：Insulin-like growth factor-1(IGF-1)is an active protein polypeptide closely related to the physiological process of growth hormone,which can promote the metabolism of sugars,lipids,proteins and inorganic salts. In order to expand the application prospect of IGF-1 in the medical field,researchers are actively developing IGF-1 derivatives due to the adverse drug reaction brought by its long-term use,which greatly restrict its application. In this paper,the derivatives of truncated IGF-1,lengthened IGF-1,IGF-1-Fc fusion protein,pegylated IGF-1 synthesized by genetic engineering and molecular biology technology were reviewed,and the excellent biological functions of IGF-1 derivatives were explained,they provide guidance for the research and development of other protein drugs in the future.
[1]司权.血清胰岛素样生长因子-1与高血压前期的关系的研究[D].天津：天津医科大学，2013.
[2]黄春琳.胰岛素样生长因子1和肾脏疾病的相关性研究[J].中国医药指南，2018,16(34):24-25.
[3]马龙飞，李娟，冯赓.胰岛素样生长因子1基因多态性与多囊卵巢综合征相关性研究[J].分子诊断与治疗杂志，2018,10(6):406-410.
[4]邹晓岚，叶茸茸，王洋，等.胰岛素样生长因子-1及其受体在肿瘤中的研究进展[J].重庆医学，2018,47(18):2474-2476,2479.
[5]陈兆君. 37例胰岛素样生长因子-1与前列腺癌的相关性研究[D].大连：大连医科大学，2018.
[6]凌浩，侯秀伟，杨闯，等.胰岛素样生长因子-1在心血管老化中的研究进展[J].心血管病学进展，2019,40(2):215-218.
[7] FRATER J,LIE D,BARTLETT P,et al. Insulin-like growth factor 1(IGF-1)as a marker of cognitive decline in normal ageing:a review[J]. Ageing Research Reviews,2018,42(3):14-27.
[8]贾寅星.胰岛素样生长因子-1衍生物的分子设计与药物开发[J].煤炭与化工，2015,38(4):30-34,134.
[9]杨彦明.室间隔缺损患儿介入治疗前后血清IGF-1和IGFBP-3水平的变化及其与心功能的关系[D].石家庄：河北医科大学，2017.
[10]杨占清. IGF-1在梅花鹿茸角再生过程中的作用及其调控机理[D].长春：吉林大学，2017.
[11]李保山.中老年男性血清胰岛素样生长因子-1水平变化及其与胰岛素抵抗和动脉硬化的关系[D].合肥：安徽医科大学，2015.
[12]于英奇，李建安，夏鹏，等.胶原结合域改良胰岛素样生长因子（CBD-IGF-1）对预防大鼠早期坐骨神经挤压损伤后肌肉萎缩的研究[J].中国实验诊断学，2019,23(1):144-146.
[13] TSEROPOULOS G,MOGHADASI BOROUJENI S,BAJPAIVIVEK K,et al. Derivation of neural crest stem cells from human epidermal keratinocytes requires FGF-2,IGF-1,and inhibition of TGF-β1[J]. Bioengineering&Translational Medicine,2018,3(3):256-264.
[14] WANG R,ZHANG H,LI S,et al. miR-186-5p promotes apoptosis by targeting IGF-1 in Sh-Sy5y Ogd/R model[J]. International Journal of Biological Sciences,2018,14(13):1791-1799.
[15]张克伟，陈华谱，江东能，等.金钱鱼IGF-1和IGF-2的克隆及其在胚胎发育过程的表达[J].广东海洋大学学报，2018,38(2):7-14.
[16]卢劲晔，王锦峰，卢炜，等.胰岛素样生长因子1研究进展[J].畜牧与兽医，2014,46(5):116-118.
[17]王凤玲，邓海荣，刘玉枝，等.碘致甲状腺功能异常及其与IGF-1和IGFBP-3表达的研究进展[J].医学综述，2018,24(9):1676-1680,1686.
[18]朱婷，季军捷，姚刚.牛初乳多肽的制备及其功能研究[J].食品科技，2014,39(5):72-75.
[19]赵维玲，马祖祥，李长钢，等.牛初乳短链胰岛素样生长因子对脂蛋白（a）诱导的肾小球系膜细胞增生与转化生长因子-β1表达的影响[J].实用儿科临床杂志，2012,27(5):340-342,377.
[20]谢曌.新型猪胰岛素样生长因子-1的基因克隆及表达分析[D].成都：四川大学，2007.
[21] GUAN J,HARRIS P,BRIMBLE M,et al. The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders[J]. Expert Opinion on Therapeutic Targets,2015,19(6):85-93.
[22] KRAEHNKE M,RICHTER L,BOECK T,et al. Differential effects of IGF-1 and des(1-3)IGF-1 during chondrogenic differentiation of bone marrow-derived stromal cells[C]//Torsten Blunk:German congress of orthopedic and trauma surgery.Berlin:ACM Press,2017:324-327.
[23] ARAUJO M S A,GUASTALI M D,CASTILHO A C S,et al. 182 Effects of Igf-1 or Igf-1-Longr3 on cellular and molecular aspects of cumulus-oocyte complexes during in vitro oocyte maturation in cattle[J]. Reproduction,Fertility and Development,2016,28(1/2):222.
[24]李亚明，田常生，胡波，等.重组pEGFP-N1-IGF-Ⅰ基因表达质粒促进SD大鼠牙囊细胞增殖及早期成骨分化效应的实验研究[J].重庆医科大学学报，2017,42(1):92-97.
[25]李建安. CBD-IGF-1的制备及复合PLGA导管在神经损伤修复中的作用[D].长春：吉林大学，2018.
[26]陈骥，王君俊，张旻，等. minTBP-1/IGF-1融合蛋白钛涂层对高糖高脂环境下成骨细胞分化活性的影响[J].现代生物医学进展，2017,17(29):5611-5617,5664.
[27]诺华股份有限公司.稳定化的胰岛素样生长因子多肽：中国，201380066090.8[P]. 2015-12-02.
[28]瑞阳（苏州）生物科技有限公司. FGF21与IGF-1的融合蛋白及其应用：中国，201710085047.6[P]. 2018-08-24.
[29] REGENERON PHARMACEUTICALS,Inc. Methods of treating obesity with combination therapeautics of Igf-1 fusion polypeptides：欧洲，2241575[P]. 2010-10-20.
[30] LIMITED LIABILITY COMPANY BIOCHEMICAL AGENT. Fusion protein,polynucleotide,genetic construct,producer,preparation for regeneration of cartilage(Variants）：国际，2017RU00521[P]. 2018-01-18.
[31] KLETZL H,GUENTHER A,H?FLICH A,et al. First-in-man study with a novel PEGylated recombinant human insulinlike growth factor-I[J]. Growth Hormone&IGF Research,2017,33(1):9-16.
[32] SAENGER S,HOLTMANN B,NILGES M R,et al. Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity[J]. Amyotrophic Lateral Sclerosis,2012,13(5):418-429.
[33] SAENGER S,GOELDNER C,FREY J R,et al. PEGylation enhances the therapeutic potential for insulin-like growth factor I in central nervous system disorders[J]. Growth Hormone&IGF Research,2011,21(5):292-303.
[34] GEHRIG S M,VAN DER POEL C,HOEFLICH A,et al. Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy[J]. Growth Hormone&IGF Research,2012,22(2):69-75.
基本信息:
DOI：10.16389/j.cnki.cn42-1737/n.2019.06.011
中图分类号:R977.15
引用信息:
[1]谢倩,李佳楠.胰岛素样生长因子-1衍生物的研究进展[J].江汉大学学报(自然科学版),2019,47(06):555-562.DOI:10.16389/j.cnki.cn42-1737/n.2019.06.011.
基金信息: