江汉大学学报（自然科学版）

目的:观察国产重组人粒细胞集落刺激因子防治肿瘤化疗所致白细胞减少的疗效及不良反应。方法:对69例经病理确诊的恶性肿瘤患者,随机分为两组:观察组35例,普药组34例。观察组应用rhG-CSF150g/d,1⁵d,皮下注射。普药组则选用利血生等普通药物治疗,连续口服7d。当中性粒细胞绝对数(ANC)降至最低值后回升超过5×109/L达2次以上停药。结果:两组患者治疗前后白细胞总数平均值及ANC平均值的差异有统计学意义(P<0.05)。不良反应有轻度骨痛或肌痛、乏力。结论:rhG-CSF可减轻化疗后ANC降低程度,缩短ANC减少的持续时间,促进ANC的恢复,降低感染发热的发生机会,无明显毒副反应,可作为肿瘤化疗中有价值的辅助药物。

Objective: To observe the curative effect and adverse reaction of rhG-CSF on theleucocyte reduction of malignant tumor patients after chemotherapy. Methods:69 malignant tumourpatients, diagnosed definitely by pathology were divided into two groups at random: 35 cases inobservation group, 34 cases in general medicine group. Observe the group and use rhG-CSF 150g/d, for 1 ~ 5 days, hypodermic injection. The general medicine group selects drug therapy, suchas leucogen, etc. for use, take 7ds orally in succession. Stop the drug after ANC drop to minimumvalue and then going up exceed 5×109/L 2 times or more than 2 times. Results:The changes of theaverage of the total amount of leucocytes and ANC average had remarkable difference before andafter two groups of patients treated (P < 0.05). There are the bad reactions slight bone aches or theskin aches, weak. Conclusion:rhG-CSF can reduce the ANC reduction after chemotherapy, thereis no obvious poisonous and side reaction, it can be regarded as the valuable auxiliary medicine intumour chemotherapy.