江汉大学学报（自然科学版）

目的评价新吾穴针刺结合核酪注射液穴位注射对常年性变应性鼻炎患者的疗效。方法选取过敏性鼻炎患者95例,随机分为治疗组47例,给予新吾穴针刺结合核酪注射液穴位注射治疗,对照组48例,给予盐酸西替利嗪分散片口服。两周为一个疗程,共治疗两个疗程。比较两组患者治疗前后血清相关因子:IgE、组胺(HIS)、白介素4(IL-4)水平及鼻结膜炎生存质量量表(RQLQ)评分变化。结果①两组在治疗后血清IgE、HIS、IL-4水平都有不同程度下降,组内比较差异有统计学意义(P <0. 05),治疗组下降幅度明显大于对照组,与对照组比较差异有统计学意义(P <0. 05)。②两组治疗后RQLQ量表评分明显降低,组内比较差异有统计学意义(P <0. 05),组间比较差异有统计学意义(P <0. 05)。③疗效比较,治疗组有效率(89. 36%)明显高于对照组(50. 08%),差异有统计学意义(P <0. 05)。结论与盐酸西替利嗪分散片相比较,针刺新吾穴结合核酪注射液穴位注射可明显改善过敏性鼻炎患者生活质量及炎症水平,疗效明显。

Objective To evaluate the effect of acupuncture combined with nucleolide and casein injection at Xinwu acupoint on patients with perennial allergic rhinitis. Methods 95 patients with allergic rhinitis were randomly divided into treatment group(n = 47),treated with acupuncture combined with nucleolide and casein injection at Xinwu acupoint;and control group(n = 48),treated with oral dispersion of cetirizine hydrochloride. Two weeks are a course of treatment for two courses. Serum related factors: IgE,histamine(HIS),interleukin 4(IL-4) levels and rhinoconjunctivitis quality of life scale(RQLQ) scores were compared between the two groups. Results ① The levels of serum IgE,HIS and IL-4 in the two groups decreased after treatment,the difference in the two groups was statistically significant(P < 0. 05). The decrease in the treatment group was significantly greater than that in the control group,it was statistical significance(P < 0. 05). ② The scores of RQLQ in the two groups were significantly lower after treatment,the difference in the groups was statistically significant(P < 0. 05). The difference between the two groups was statistically significant(P < 0. 05). ③ The efficacy was compared,the effective rate of the treatment group was 89. 36%,which was significantly higher than that of the control group(50. 08%),the difference was statistically significant. Conclusion Compared with the treatment of cetirizine hydrochloride dispersible tablets, acupuncture combined with nucleolide and casein injection at Xinwu acupoint can significantly improve quality of life and relieve inflammation of patients with allergic rhinitis.